GS-441524 Therapy for Feline Infectious Peritonitis (FIP).
Feline Infectious Peritonitis (FIP) is a severe and often fatal disease caused by certain strains of the feline coronavirus (FCV). FIP causes inflammation of the abdominal lining (peritonitis) and can lead to fluid accumulation, and severe organ damage.
The disease manifests in two major forms: the “wet” form, characterized by fluid buildup in the abdomen or chest, and the “dry” form, which leads to the formation of granulomas in organs like the liver, kidneys, and brain.
Feline infectious peritonitis can be challenging to diagnose because its symptoms can be similar to those of other diseases. The symptoms can also vary depending on whether the disease is in its “wet” or “dry” form. See common symptoms of FIP below.
Cats with FIP often have a fever that does not respond to antibiotics.
Affected cats may become very lethargic and show a lack of energy.
Significant and unexplained weight loss is common in cats with FIP.
Cats may refuse to eat, leading to further weight loss and weakness.
Fluid buildup in the abdomen can cause a swollen, pot-bellied appearance.
Fluid in the chest can lead to breathing difficulties.
Jaundice, increased thirst, and urination may occur if the liver or kidneys are affected.
Cats may show signs such as unsteady gait, seizures, or behavioral changes if the brain is involved.
Eye inflammation and other eye-related issues can occur.
Avrio Pharmacy is proud to introduce compounded GS tablets and a NEW oral suspension, a promising option for cats suffering from feline infectious peritonitis. GS-441524 (GS), the active ingredient in our GS tablets and oral suspension, is an antiviral drug (nucleoside analog) that has shown significant success in curing cats with FIP in field trials conducted at UC Davis by Dr. Niels Pedersen and his team. However, it’s important to note that while GS tablets and oral suspension have shown promise, they do not guarantee a cure for every cat with FIP.
Ease of use: Compounded GS-441524 comes in a convenient, small 50 mg tablet that can easily be divided into quarters. This lets you adjust the dose as needed based on your cat’s weight and clinical improvement, without the hassle of ordering multiple strengths.
Promising Results: GS-441524 has demonstrated success in clinical trials, providing a potential treatment option for cat owners and veterinarians.
Convenient Dosing: The tablets are compounded with four scores to help facilitate necessary dosage adjustments and minimize stress during administration.
Quality Matters: Avrio only sources the active ingredient, GS-441524, from FDA registered wholesalers. We also inspect all certificates of analysis prior to use to ensure all lots have undergone internal quality measures to ensure the safety of our compounded product.
Ease of Use: Avrio’s compounded GS-441524 oral suspension offers a liquid formulation, making it an excellent option for cats who have difficulty taking tablets. The suspension allows for dosing tailored to your cat’s weight and clinical improvement.
Promising Results: GS-441524 has demonstrated success in clinical trials, providing a potential treatment option for cat owners and veterinarians. The liquid formulation offers an alternative for cats who may struggle with solid medications.
Convenient Dosing: Avrio’s GS-441524 oral suspension can be measured and administered using an oral syringe (as shown) or a dropper.
Quality Matters: Avrio only sources the active ingredient, GS-441524, from FDA-registered wholesalers. We also inspect all certificates of analysis prior to use to ensure all lots have undergone internal quality measures to ensure the safety of our compounded product.
Treatment Duration: The recommended treatment is up to 12 weeks of daily oral compounded GS-441524. A typical 12-week treatment course includes blood work being checked at diagnosis, day 30, day 60, and day 80 (just before the end of the treatment period) to confirm if the treatment can be stopped. Always follow your veterinarian’s recommendations.
Administration: Oral tablets are given once daily and are dosed based on the cat’s weight, the type of FIP being treated, and the clinical response after treatment initiation. Some cases may require twice daily dosing.
Side Effects: The oral formulations may cause mild GI upset, lethargy, increased thirst, and temporary elevated kidney/liver values (which typically resolve after stopping treatment).
Need to calculate the right medication dosage for your cat?
(This is not an all-inclusive list)
If you have any questions about GS-441524 or would like to discuss treatment options for a cat with feline infectious peritonitis, please don’t hesitate to contact us. Our knowledgeable staff is here to assist you and provide the support you need.
Veterinarians! You can easily submit new prescriptions to our pharmacy team via phone, fax, or by using our free online prescribing platform for veterinarians at order.avriorx.com.
If your cat vomits within 1 hours of administering the pill(s), it is typically recommended to give another full dose. Always check with your veterinarian or care team member to discuss dosing questions.
Oral dosing with GS will require a higher dose of the tablet to account for differences in the bioavailability of the tablet versus the injectable.
There are many online pharmacies that sell GS tablets among other medications. Most of the pharmacies are located outside of the US and are not sourcing their active ingredients from FDA registered wholesalers. The FDA often warns about the risks from ordering from unknown sources. At Avrio Pharmacy, we only source GS-441524 from FDA registered wholesalers and review a certificate of analysis (CoA) prior to dispensing to any patients.
FIP is not contagious and therefore not necessary to separate your FIP kitty from other cats in the home.
A lot of cats develop diarrhea in the beginning of treatment. Using a probiotic, 100% pumpkin puree, B12 injections, or antibiotics like metronidazole may be several options that your veterinarian may recommend.
You or your provider may reach our pharmacy team at 480-270-6700 weekdays 8:30 am to 5:30 pm Arizona time and Saturday 9:00 am to 2:00 pm. We have dedicated phone lines for both patients and providers to connect the most appropriate team (human compounding, veterinary medicine, retail pharmacy). We do close for major holidays, which may impact our phone hours.
You may also visit our pharmacy in-person weekdays 8:00 am-6:00 pm and Saturday 9:00a-2:00p Arizona time to speak with a member of our team.
